Drug Database: Atovaquone

What is atovaquone? What is atovaquone?

What is atovaquone?

Atovaquone is an antiprotozoal prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the prevention and treatment of Pneumocystis pneumonia (PCP) in adults and adolescents who cannot tolerate sulfamethoxazole/trimethoprim.

PCP can be an opportunistic infection (OI) of HIV. An OI is an infection that occurs more frequently or is more severe in people with weakened immune systems—such as people with HIV—than in people with healthy immune systems. To learn more about OIs, read the HIVinfo What is an Opportunistic Infection? fact sheet.

How is atovaquone used in people with HIV? How is atovaquone used in people with HIV?

How is atovaquone used in people with HIV?

The Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents With HIV and/or the Guidelines for the Prevention and Treatment of Opportunistic Infections in Children With and Exposed to HIV include recommendations on the use of atovaquone in people with HIV to:

Treat:

• PCP
• Toxoplasma gondii encephalitis

Prevent:

• PCP from occurring the first time and from recurring
• Toxoplasma gondii encephalitis from occurring the first time and from recurring

The recommended uses may not always be consistent with FDA-approved uses of atovaquone. See the Adult and Pediatric Opportunistic Infection Guidelines for complete information on recommended uses of atovaquone in adults and children with HIV. Atovaquone may have other recommended uses not listed above.

What should I tell my health care provider before taking atovaquone? What should I tell my health care provider before taking atovaquone?

What should I tell my health care provider before taking atovaquone?

Before taking atovaquone, tell your health care provider:

• If you are allergic to atovaquone or any other medicines.
• About any medical conditions you have or have had, including liver problems or gastrointestinal disorders.
• About anything that could affect your ability to take atovaquone, such as difficulty taking an oral suspension (a liquid) with food or trouble remembering a scheduled dose.
• If you are pregnant or plan to become pregnant. Talk to your health care provider about the risks and benefits of taking atovaquone during pregnancy. The Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents With HIV may include other recommendations on the use of atovaquone during pregnancy. Please refer to these guidelines for additional information.
• If you are breastfeeding or plan to breastfeed. For mothers with HIV in the United States, the Guideline recommends speaking with your health care provider to discuss options for feeding your baby. Mothers with suppressed viral load have a less than 1% chance of transmitting HIV to their baby via their own milk. Although most medicines are safe to use while breastfeeding, some medicines should be avoided. Always let your health care provider know about all the medicines and supplements you are using before you start breastfeeding.
• About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Atovaquone may affect the way other medicines or products work, and other medicines or products may affect how atovaquone works. Ask your health care provider if there are interactions between atovaquone and the other medicines you take.

How should I take atovaquone? How should I take atovaquone?

How should I take atovaquone?

Take atovaquone according to your health care provider’s instructions. Your health care provider will tell you how much atovaquone to take and when to take it. Before you start atovaquone and each time you get a refill, read any printed information that comes with your medicine.

What side effects can atovaquone cause? What side effects can atovaquone cause?

What side effects can atovaquone cause?

Atovaquone may cause side effects that can be mild or serious. To learn about possible side effects of atovaquone, see the FDA drug label or talk to your health care provider or pharmacist. Tell your health care professional if you have any side effect that bothers you or that does not go away. Your health care professional may be able to tell you about ways to prevent or reduce some side effects.

You may report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online.

How should atovaquone be stored? How should atovaquone be stored?

How should atovaquone be stored?

• Store atovaquone oral suspension between 59°F and 77°F (15°C and 25°C). Do not freeze the oral suspension.
• Keep atovaquone in the container that it came in and keep the container tightly closed.
• Do not use atovaquone if the original seal over the container opening is broken or missing.
• Throw away atovaquone that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
• Keep atovaquone and all medicines out of reach of children.

Where can I find more information about atovaquone? Where can I find more information about atovaquone?

Where can I find more information about atovaquone?

• Recommendations on the HIV-related uses of atovaquone, from the Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents With HIV and the Guidelines for the Prevention and Treatment of Opportunistic Infections in Children With and Exposed to HIV.
• This Patient Version drug summary is based on the following FDA label(s): Suspension. The Patient Counseling Information section of the label includes information for people taking atovaquone.
• The American Hospital Formulary Service (AHFS) Patient Medication Information for atovaquone available from MedlinePlus.
• Atovaquone-related research studies, from ClinicalTrials.gov. (The ClinicalTrials.gov search can be modified so that you can get results that better match your interests.)